TECENTRIQ Dosing and Administration 

TECENTRIQ provides established dosing options across all indications

Non-small cell lung cancer (NSCLC)

Indications1

TECENTRIQ, in combination with bevacizumab, paclitaxel and carboplatin, is indicated for the first-line treatment of adult patients with metastatic non-squamous non-small cell lung cancer (NSCLC). In patients with EGFR mutant or ALK-positive NSCLC, TECENTRIQ, in combination with bevacizumab, paclitaxel and carboplatin, is indicated only after failure of appropriate targeted therapies.

 

TECENTRIQ, in combination with nab-paclitaxel and carboplatin, is indicated for the first-line treatment of adult patients with metastatic non-squamous NSCLC who do not have EGFR mutant or ALK-positive NSCLC.

 

TECENTRIQ as monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic NSCLC after prior chemotherapy. Patients with EGFR mutant or ALK+ NSCLC should also have received targeted therapy before receiving TECENTRIQ.

 

1L Metastatic non-squamous NSCLC

 

TECENTRIQ in combination with bevacizumab, paclitaxel and carboplatin.

A consistent infusion schedule with chemotherapy-free post-induction dosing.

 

Infusions once every 3 weeks1,2

1L=first line; AUC=area under the concentration-time curve; IV=intravenous; NSCLC=non-small cell lung cancer.
Based on the dosing schedule from IMpower150.2 Visualization of vials is illustrative and does not represent actual vial usage.
*In patients of Asian race/ethnicity, the paclitaxel dose was lowered from 200 mg/m2 to 175 mg/m2

  • TECENTRIQ should be administered prior to bevacizumab, paclitaxel, and carboplatin on Day 1 of each cycle
  • Administer the initial infusion of TECENTRIQ over 60 minutes; if the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes
  • Do not administer TECENTRIQ as an IV push or bolus
  • Do not co-administer other drugs through the same IV line
  • Refer to the respective prescribing information for bevacizumab, paclitaxel, and carboplatin for recommended dosing information

TECENTRIQ in combination with nab-paclitaxel and carboplatin.

 

Induction phase followed by chemotherapy-free infusions with TECENTRIQ.

 

Infusions once every 3 weeks1,3

1L=first line; AUC=area under the concentration-time curve; IV=intravenous; nab-pac=nanoparticle albumin–bound paclitaxel; NSCLC=non-small cell lung cancer.

Based on the dosing schedule from IMpower130.3 Visualization of vials is illustrative and does not represent actual vial usage.

  • For each 21-day cycle, TECENTRIQ, nab-pac, and carboplatin are administered on Day 1; in addition, nab-pac is administered on days 8 and 15
  • Administer the initial infusion of TECENTRIQ over 60 minutes; if the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes
  • Do not administer TECENTRIQ as an IV push or bolus
  • Do not co-administer other drugs through the same IV line
  • Refer to the respective prescribing information for the combination products

2L Metastatic NSCLC

 

TECENTRIQ as monotherapy

 

TECENTRIQ offers flexible dosing options

 

Choose the most suitable infusion schedule for your patients1,4

Q4W dosage is administered with two 840-mg vials of TECENTRIQ.

Visualization of vials is illustrative and does not represent actual vial usage.

2L=second line; IV=intravenous; Q4W=every 4 weeks.

  • Do not administer TECENTRIQ as an IV push or bolus
  • Do not co-administer other drugs through the same IV line

Small Cell Lung Cancer (SCLC)

Indications1

TECENTRIQ, in combination with carboplatin and etoposide, is indicated for first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC).

 

TECENTRIQ, in combination with carboplatin and etoposide

 

TECENTRIQ Infusion Schedule with Chemotherapy-Free Maintenance

 

Q3W combination induction followed by flexible dosing options in maintenance1, 5

Dosing information for carboplatin/etoposide is based on IMpower133 trial;

TECENTRIQ was administered Q3W in IMpower133.5 Visualization of vials is illustrative and does not represent actual vial usage.

Q3W=every 3 weeks

  • During induction phase, TECENTRIQ should be administered by IV infusion first, followed by carboplatin, then etoposide
  • During maintenance phase, TECENTRIQ can be administered as 1200 mg every 3 weeks
  • Administer the initial infusion of TECENTRIQ over 60 minutes; if the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes
  • Do not administer TECENTRIQ as an IV push or bolus
  • Do not co-administer other drugs through the same IV line
  • Refer to the respective prescribing information for carboplatin and etoposide for recommended dosing information

Triple-negative Breast Cancer (TNBC)

Indication4

TECENTRIQ in combination with nab-paclitaxel (nab-pac) is indicated for the treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumours have PD-L1 expression ≥1% and who have not received prior chemotherapy for metastatic disease.

 

TECENTRIQ in combination with nab-paclitaxel.

 

Dosing Schedule Allows Patients an Infusion-Free Week Between Cycles

 

28-day dosing cycles continue until disease progression or unacceptable toxicity4,6

nab-pac=nanoparticle albumin–bound paclitaxel.

Based on the dosing schedule from IMpassion130.6

Visualization of vials is illustrative and does not represent actual vial usage.

  • For each 28-day cycle, TECENTRIQ is administered on Days 1 and 15, and nab-pac 100 mg/m2  is administered on Days 1, 8, and 15
  • On Days 1 and 15, TECENTRIQ should be administered first, followed by nab-pac
  • Administer the initial infusion of TECENTRIQ over 60 minutes; if the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes
  • Do not administer TECENTRIQ as an IV push or bolus
  • Do not co-administer other drugs through the same IV line
  • TECENTRIQ and nab-pac may be discontinued for toxicity independently of each other
  • See also the prescribing information for nab-pac prior to initiation

840-mg single-dose vial now approved for TECENTRIQ

Urothelial carcinoma

Indications1,4

TECENTRIQ as monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma (mUC):

  • After prior platinum containing chemotherapy, or
  • Who are considered cisplatin ineligible, and whose tumours have a PD-L1 expression ≥5%

 

TECENTRIQ as monotherapy

TECENTRIQ Offers Flexible Dosing Options

 

Choose the most suitable infusion schedule for your patients1,4

Visualization of vials is illustrative. Q4W dosage is administered with two 840-mg vials of TECENTRIQ.
IV=intravenous; q3w=every 3 weeks.

  • Do not administer as an IV push or bolus
  • Do not co-administer other drugs through the same IV line

Dose Modifications for TECENTRIQ1,4

 

No dose reductions of TECENTRIQ are recommended.

 

Dose modification advice for TECENTRIQ

IMMUNE-RELATED ADVERSE REACTION

SEVERITY OF ADVERSE REACTION

DOSAGE MODIFICATIONS

Pneumonitis

Grade 2

Withhold TECENTRIQ

Treatment may be resumed when the event improves to Grade 0 or Grade 1within 12 weeks, and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 3 or 4

Permanently discontinue

TECENTRIQ

Hepatitis

Grade 2:

(ALT or AST >3 or 5 x ULN

or

blood bilirubin >1.5 to 3 x ULN)

Withhold TECENTRIQ

Treatment may be resumed when the event improves to Grade 0 or Grade 1 within 12 weeks and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 3 or 4:

(ALT or AST >5 x ULN

or

blood bilirubin >3 x ULN)

Permanently discontinue

TECENTRIQ

Colitis

Grade 2 or 3 diarrhoea

(increase of ≥4 stools/day over baseline)

or

symptomatic colitis

Withhold TECENTRIQ

 

Treatment may be resumed when the event improves to Grade 0 or Grade 1within 12 weeks and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 4 diarrhoea or colitis (life threatening; urgent intervention indicated)

Permanently discontinue

TECENTRIQ

Hypothyroidism or

hyperthyroidism

Symptomatic

Withhold TECENTRIQ

 

Hypothyroidism:

Treatment may be resumed when symptoms are controlled by thyroid replacement therapy and TSH levels are decreasing

Hyperthyroidism:

Treatment may be resumed when symptoms are controlled by anti-thyroid medicinal product and thyroid function is improving

Adrenal insufficiency
Symptomatic

Withhold TECENTRIQ

Treatment may be resumed when the event improves to Grade 0 or Grade 1 within 12 weeks and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Hypophysitis

Grade 2 or 3

Withhold TECENTRIQ

Grade 4

Permanently discontinue TECENTRIQ

Type 1 diabetes

Grade 3 or 4 hyperglycaemia (fasting glucose >250 mg/dL or 13.9 mmol/L)

Withhold TECENTRIQ

Treatment may be resumed when metabolic control is achieved on insulin replacement therapy

Infusion related reactions

Grade 1 or 2

Reduce infusion rate or interrupt. Treatment may be resumed when the event is resolved

Grade 3 or 4

Permanently discontinue

TECENTRIQ

Rash

Grade 3

Withhold TECENTRIQ

Treatment may be resumed when rash is resolved and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 4

Permanently discontinue

TECENTRIQ

Myasthenic

syndrome/myasthenia gravis,

Guillain-Barré syndrome

and Meningoencephalitis

All grades

Permanently discontinue

TECENTRIQ

Pancreatitis

Grade 3 or 4 serum amylase or lipase levels increased (>2 x

ULN) or Grade 2 or 3 pancreatitis

Withhold TECENTRIQ

Treatment may be resumed when serum amylase and lipase levels improve to Grade 0 or Grade 1 within 12 weeks, or symptoms of pancreatitis have resolved, and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 4 or any grade of recurrent pancreatitis

Permanently discontinue

TECENTRIQ

Myocarditis
Grade 2

Withhold TECENTRIQ

Treatment may be resumed when the symptoms improve to Grade 0 or Grade 1 within 12 weeks and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 3 or 4

Permanently discontinue

TECENTRIQ

Nephritis

Grade 2

(creatinine level >1.5 – 3.0 x baseline or >1.5 - 3.0 x ULN)

Withhold TECENTRIQ

Treatment may be resumed when the event improves to Grade 0 or Grade 1 within 12 weeks and corticosteroids have been reduced to ≤10 mg prednisone or equivalent per day

Grade 3 or 4

(creatinine level >3.0 x baseline or >3.0 x ULN)

Permanently discontinue

TECENTRIQ

Myositis
Grade 2 or 3
Withhold TECENTRIQ
Grade 4 or grade 3 recurrent myositis

Permanently discontinue

TECENTRIQ

Other immune-related

adverse reactions

Grade 2 or 3
Withhold until adverse reactions recovers to Grade 0-1 within 12 weeks, and corticosteroids have been reduced to ≤ 10 mg prednisone or equivalent per day. 
Grade 4 or recurrent Grade 3

Permanently discontinue

TECENTRIQ

(except endocrinopathies controlled with replacement hormones)

No filter results

Note: Toxicity grades are in accordance with National Cancer Institute Common Terminology Criteria for Adverse Event. Version 4.0 (NCI-CTCAE v.4.).

RESOURCES

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Connecting YOU WITH YOUR PATIENTS

CONNECTING YOU WITH YOUR PATIENTS

At Roche, we believe in a shared purpose in improving the care and treatment of patients living with difficult to treat cancers. We understand and empathise with the demands you face managing the needs of these patients.

Roche is committed to exploring new treatment options to individualise treatment and meet patients’ needs. TECENTRIQ has proven efficacy as monotherapy as well as in combination with other medicines and we are committed to exploring new combinations to improve patient outcomes (ref. SmPC). 

TECENTRIQ is an anti PD-L1 cancer immunotherapy that specifically targets PD-L1 on tumour and tumour-infiltrating immune cells across a broad range of solid tumours. TECENTRIQ offers a pioneering, targeted treatment with proven efficacy and an acceptable tolerability profile (ref. SmPC). Please see the specific indications for more information.

Connecting TECENTRIQ and COMBINATIONS

CONNECTING TECENTRIQ AND COMBINATIONS

TECENTRIQ has proven efficacy as monotherapy as well as in combination with other medicines and we are committed to explore new combinations for better patient outcomes (ref. SmPC).

In many difficult-to-treat tumour types with a high unmet need, including metastatic urothelial carcinoma, triple negative breast cancer and lung cancer (non-small cell lung cancer and small cell lung cancer), TECENTRIQ has shown significant improvements in progression-free and/or overall survival (ref. SmPC). Importantly, treatment can be tailored (i.e., in combination with the standard of care, or different dosing schedules) according to the type of cancer and the patient’s individual needs (ref. SmPC).
Read SmPC for more details

The multiple indications of TECENTRIQ (ref. SmPC)
provide a wealth of data to inform treatment decision-making and deliver valuable reassurance when considering the needs of your patients with cancer. Please see the specific indications for more information.

Connecting PATIENTS TO THEIR LOVED ONES

CONNECTING PATIENTS TO THEIR LOVED ONES

TECENTRIQ treatment offers the potential to improve treatment outcomes and maintain patient quality of life in your difficult to treat cancer patients, so they can hopefully spend more time with their loved ones.

TECENTRIQ is approved in metastatic urothelial carcinoma, non-small cell lung cancer, extensive-stage small cell lung cancer and triple negative breast cancer (ref. SmPC).

  • References & Notes

    References & Notes

    1. Tecentriq 1,200 mg concentrate for solution for infusion. Summary of Product Characteristics. Updated 10-Jun-2020 | Roche Products Limited. Available from: https://www.medicines.org.uk/ (Accessed September 2020).
    2. Socinski MA, et al; IMpower150 Study Group. Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N Engl J Med. 2018;378:2288–301.
    3. West H, et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2019;20(7):924–37.
    4. Tecentriq 840 mg concentrate for solution for infusion. Summary of Product Characteristics. Updated 2-Sep-2020 | Roche Products Limited. Available from: https://www.medicines.org.uk/ (Accessed September 2020).
    5. Horn L, et al. IMpower133 Study Group. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. N Engl J Med. 2018;379:2220–9.
    6. Schmid P, et al; IMpassion130 Trial Investigators. Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer. N Engl J Med. 2018;379:2108–21.